excellent questions jake, i have often pondered those questions too. in the bible, everyone will/has heard of God. that is in scripture. Jesus will not come again until soul has heard the gospel, along with many other factors. I believe, especially in today's times, that it is nearly impossible for someone not to have heard of God before. whether it be missionaries or internet or radio or whatever. in the past this wasn't so easy. without technology, things were much more difficult. there were many missionaries in the world though. and although they could not reach everyone, i believe that by word of mouth most got to hear it. even if that is just wishful thinking, every culture/race/whatever believes in a higher being. could this be a born trait given by God, i think so.
im sorry if these don't seem to logical to you, it is something that i am still researching. i do believe though that everyone will hear the grace of God before they die though.
as for the handicapped and even infants if you want, i believe that there is a place for them in the gates of heaven. when children die young, or are born with severe mental retardation, i believe that they will enter heaven
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